Sankey Plots
New sankey plot for Hospital Admission
## [1] "Has cargado los datos correctamente. Aquí tienes tu gráfico:"
New sankey plot for ICU Admission
## [1] "Has cargado los datos correctamente. Aquí tienes tu gráfico:"
New sankey plot for mortality
## [1] "Has cargado los datos correctamente. Aquí tienes tu gráfico:"
Sankey Plot for Hospital Admission
Sankey Plot for UCI Admission
Sankey Plot for Mortality
Variants distribution in Spain
Option A
Option B
Comparative analysis before-after vaccination campaigns
Hospital Admission, before VS after vaccines
Odds Ratios and Confidence Intervals for hospital admission-associated factors. (1) refers to the subgroup of cases ocurred prior to vaccine introduction. (2) refers to the subgroup of cases ocurred after 75% vaccine coverage was reached
|
Hospital admission-associated factors
|
Odds Ratio (1)
|
Odds Ratio lower CI limit (1)
|
Odds Ratio upper CI limit (1)
|
p value (1)
|
Odds Ratio (2)
|
Odds Ratio lower CI limit (2)
|
Odds Ratio upper CI limit (2)
|
p value (2)
|
|
Gender (male)
|
1.8350669
|
1.7839436
|
1.8876552
|
0.0000000
|
1.7247955
|
1.6640000
|
1.7878122
|
0.0000000
|
|
Age (group 1: 12-43)
|
0.8118844
|
0.7664951
|
0.8599614
|
0.0000000
|
2.4665347
|
2.2167023
|
2.7445242
|
0.0000000
|
|
Age (group 2: 44-74)
|
5.9585658
|
4.6860145
|
7.5766958
|
0.0000000
|
7.5581850
|
6.0628029
|
9.4224011
|
0.0000000
|
|
Age (group 3: >74)
|
2.3814633
|
2.1316832
|
2.6605115
|
0.0000000
|
0.9652859
|
0.8418606
|
1.1068067
|
0.6127464
|
|
Asthma
|
1.2287899
|
1.1753933
|
1.2846122
|
0.0000000
|
1.0202247
|
0.9634452
|
1.0803504
|
0.4931314
|
|
Ischemic heart disease
|
0.9680384
|
0.9127130
|
1.0267174
|
0.2793233
|
1.0240454
|
0.9675177
|
1.0838757
|
0.4121275
|
|
Hepatic cirrhosis
|
1.0056350
|
0.8573855
|
1.1795181
|
0.9449455
|
1.4279450
|
1.2092460
|
1.6861970
|
0.0000267
|
|
Diabetes
|
1.3391670
|
1.2925427
|
1.3874731
|
0.0000000
|
1.3206591
|
1.2692835
|
1.3741142
|
0.0000000
|
|
Chronic Obstructive Pulmonary Disease (COPD)
|
1.2463781
|
1.1881478
|
1.3074622
|
0.0000000
|
1.4478635
|
1.3790475
|
1.5201135
|
0.0000000
|
|
Chronic Hepatic Disease (except cirrhosis)
|
1.1909838
|
1.1048274
|
1.2838589
|
0.0000051
|
1.2824422
|
1.1780216
|
1.3961188
|
0.0000000
|
|
Hypertension
|
1.2486174
|
1.2079611
|
1.2906419
|
0.0000000
|
1.2813084
|
1.2253578
|
1.3398136
|
0.0000000
|
|
Heart failure
|
1.4316533
|
1.3543820
|
1.5133332
|
0.0000000
|
1.6291463
|
1.5522394
|
1.7098637
|
0.0000000
|
|
Chronic kidney disease
|
1.6826809
|
1.5820150
|
1.7897523
|
0.0000000
|
1.6120382
|
1.5280995
|
1.7005875
|
0.0000000
|
|
HIV+
|
1.1983782
|
0.9587784
|
1.4978543
|
0.1118140
|
1.7763850
|
1.3671217
|
2.3081660
|
0.0000170
|
|
Solid organ cancer
|
1.0770999
|
1.0244717
|
1.1324317
|
0.0036621
|
1.1703677
|
1.1112838
|
1.2325930
|
0.0000000
|
|
Haematologic cancer
|
2.4541640
|
2.1547966
|
2.7951226
|
0.0000000
|
4.3717077
|
3.8994602
|
4.9011471
|
0.0000000
|
|
Number of COVID Vaccines (1)
|
NA
|
NA
|
NA
|
NA
|
0.3405888
|
0.3143413
|
0.3690281
|
0.0000000
|
|
Number of COVID Vaccines (2)
|
NA
|
NA
|
NA
|
NA
|
0.1675847
|
0.1586083
|
0.1770691
|
0.0000000
|
|
Number of COVID Vaccines (3)
|
NA
|
NA
|
NA
|
NA
|
0.0893234
|
0.0830734
|
0.0960437
|
0.0000000
|
ICU admission, before VS after vaccines
Odds Ratios and Confidence Intervals for ICU admission-associated factors. (1) refers to the subgroup of cases ocurred prior to vaccine introduction. (2) refers to the subgroup of cases ocurred after 75% vaccine coverage was reached
|
ICU admission-associated factors
|
Odds Ratio (1)
|
Odds Ratio lower CI limit (1)
|
Odds Ratio upper CI limit (1)
|
p value (1)
|
Odds Ratio (2)
|
Odds Ratio lower CI limit (2)
|
Odds Ratio upper CI limit (2)
|
p value (2)
|
|
Gender (male)
|
2.628320e+00
|
2.430522e+00
|
2.842214e+00
|
0.0000000
|
2.438864e+00
|
2.143066e+00
|
2.775490e+00
|
0.0000000
|
|
Age (group 1: 12-43)
|
1.673597e+00
|
1.373681e+00
|
2.038993e+00
|
0.0000003
|
1.412567e+01
|
8.311261e+00
|
2.400774e+01
|
0.0000000
|
|
Age (group 2: 44-74)
|
3.897720e+05
|
1.188193e+05
|
1.278599e+06
|
0.0000000
|
3.623054e+05
|
7.034165e+04
|
1.866109e+06
|
0.0000000
|
|
Age (group 3: >74)
|
4.478120e-02
|
2.691810e-02
|
7.449860e-02
|
0.0000000
|
1.099600e-02
|
4.599600e-03
|
2.628760e-02
|
0.0000000
|
|
Asthma
|
1.228403e+00
|
1.091535e+00
|
1.382433e+00
|
0.0006422
|
1.093868e+00
|
8.893167e-01
|
1.345469e+00
|
0.3956484
|
|
Ischemic heart disease
|
9.600624e-01
|
8.310528e-01
|
1.109099e+00
|
0.5798762
|
1.163030e+00
|
9.330914e-01
|
1.449632e+00
|
0.1790167
|
|
Hepatic cirrhosis
|
8.053128e-01
|
5.490319e-01
|
1.181222e+00
|
0.2679362
|
1.146570e+00
|
6.773404e-01
|
1.940860e+00
|
0.6105412
|
|
Diabetes
|
1.516271e+00
|
1.391900e+00
|
1.651755e+00
|
0.0000000
|
1.462867e+00
|
1.260600e+00
|
1.697588e+00
|
0.0000005
|
|
Chronic Obstructive Pulmonary Disease (COPD)
|
1.037967e+00
|
9.198262e-01
|
1.171281e+00
|
0.5455582
|
8.728845e-01
|
7.115942e-01
|
1.070733e+00
|
0.1921339
|
|
Chronic Hepatic Disease (except cirrhosis)
|
1.204816e+00
|
1.011251e+00
|
1.435432e+00
|
0.0370540
|
1.312447e+00
|
9.989192e-01
|
1.724382e+00
|
0.0509145
|
|
Hypertension
|
1.309175e+00
|
1.205779e+00
|
1.421438e+00
|
0.0000000
|
1.320143e+00
|
1.144025e+00
|
1.523374e+00
|
0.0001437
|
|
Heart failure
|
9.838237e-01
|
8.403718e-01
|
1.151763e+00
|
0.8392791
|
1.105199e+00
|
8.763825e-01
|
1.393757e+00
|
0.3980515
|
|
Chronic kidney disease
|
1.194167e+00
|
1.016456e+00
|
1.402948e+00
|
0.0308883
|
1.757646e+00
|
1.405397e+00
|
2.198181e+00
|
0.0000008
|
|
HIV+
|
9.198165e-01
|
5.137179e-01
|
1.646940e+00
|
0.7785347
|
5.790259e-01
|
2.123572e-01
|
1.578807e+00
|
0.2856764
|
|
Solid organ cancer
|
7.826897e-01
|
6.814719e-01
|
8.989412e-01
|
0.0005247
|
8.800972e-01
|
7.090657e-01
|
1.092383e+00
|
0.2466622
|
|
Haematologic cancer
|
2.585304e+00
|
2.000029e+00
|
3.341849e+00
|
0.0000000
|
4.326200e+00
|
3.218729e+00
|
5.814719e+00
|
0.0000000
|
|
Number of COVID Vaccines (1)
|
NA
|
NA
|
NA
|
NA
|
2.366195e-01
|
1.894491e-01
|
2.955346e-01
|
0.0000000
|
|
Number of COVID Vaccines (2)
|
NA
|
NA
|
NA
|
NA
|
1.052790e-01
|
9.125740e-02
|
1.214550e-01
|
0.0000000
|
|
Number of COVID Vaccines (3)
|
NA
|
NA
|
NA
|
NA
|
7.571900e-02
|
6.103500e-02
|
9.393580e-02
|
0.0000000
|
30 days-mortality, before VS after vaccines
Odds Ratios and Confidence Intervals for mortality-associated factors. (1) refers to the subgroup of cases ocurred prior to vaccine introduction. (2) refers to the subgroup of cases ocurred after 75% vaccine coverage was reached
|
ICU admission-associated factors
|
Odds Ratio (1)
|
Odds Ratio lower CI limit (1)
|
Odds Ratio upper CI limit (1)
|
p value (1)
|
Odds Ratio (2)
|
Odds Ratio lower CI limit (2)
|
Odds Ratio upper CI limit (2)
|
p value (2)
|
|
Gender (male)
|
1.9387568
|
1.8183169
|
2.067174
|
0.0000000
|
1.7223374
|
1.6275419
|
1.8226543
|
0.0000000
|
|
Age (group 1: 12-43)
|
1.4048693
|
1.1341749
|
1.740171
|
0.0018527
|
1.3346317
|
1.0280160
|
1.7326985
|
0.0302016
|
|
Age (group 2: 44-74)
|
4.9644579
|
3.2455121
|
7.593822
|
0.0000000
|
2.9953752
|
2.1344949
|
4.2034642
|
0.0000000
|
|
Age (group 3: >74)
|
3.9476406
|
2.8796150
|
5.411788
|
0.0000000
|
5.6720670
|
4.0549859
|
7.9340213
|
0.0000000
|
|
Asthma
|
0.8716592
|
0.7832448
|
0.970054
|
0.0118318
|
0.7999920
|
0.7272184
|
0.8800482
|
0.0000045
|
|
Ischemic heart disease
|
1.0390226
|
0.9482325
|
1.138506
|
0.4118990
|
1.0218200
|
0.9471700
|
1.1023534
|
0.5770650
|
|
Hepatic cirrhosis
|
2.3548579
|
1.8753474
|
2.956975
|
0.0000000
|
2.1310530
|
1.7034321
|
2.6660216
|
0.0000000
|
|
Diabetes
|
1.3570787
|
1.2725460
|
1.447227
|
0.0000000
|
1.1969631
|
1.1317961
|
1.2658823
|
0.0000000
|
|
Chronic Obstructive Pulmonary Disease (COPD)
|
1.3791499
|
1.2742220
|
1.492718
|
0.0000000
|
1.2070255
|
1.1269333
|
1.2928100
|
0.0000001
|
|
Chronic Hepatic Disease (except cirrhosis)
|
1.2777068
|
1.1134259
|
1.466227
|
0.0004829
|
1.2036082
|
1.0595308
|
1.3672775
|
0.0043871
|
|
Hypertension
|
1.0299413
|
0.9556392
|
1.110021
|
0.4399746
|
1.0559415
|
0.9828945
|
1.1344172
|
0.1366877
|
|
Heart failure
|
1.4474304
|
1.3357495
|
1.568449
|
0.0000000
|
1.4896302
|
1.3992684
|
1.5858272
|
0.0000000
|
|
Chronic kidney disease
|
1.6418661
|
1.5049060
|
1.791291
|
0.0000000
|
1.6220125
|
1.5158477
|
1.7356127
|
0.0000000
|
|
HIV+
|
1.9336210
|
1.1784503
|
3.172718
|
0.0090578
|
1.7897312
|
1.0333051
|
3.0998954
|
0.0378142
|
|
Solid organ cancer
|
1.2504893
|
1.1507779
|
1.358840
|
0.0000001
|
1.3147407
|
1.2254677
|
1.4105171
|
0.0000000
|
|
Haematologic cancer
|
2.7025435
|
2.2088987
|
3.306508
|
0.0000000
|
2.9462614
|
2.5106973
|
3.4573886
|
0.0000000
|
|
Number of COVID Vaccines (1)
|
NA
|
NA
|
NA
|
NA
|
0.4889343
|
0.4185753
|
0.5711202
|
0.0000000
|
|
Number of COVID Vaccines (2)
|
NA
|
NA
|
NA
|
NA
|
0.2915335
|
0.2613189
|
0.3252416
|
0.0000000
|
|
Number of COVID Vaccines (3)
|
NA
|
NA
|
NA
|
NA
|
0.1662793
|
0.1470688
|
0.1879992
|
0.0000000
|
Sub-analyses:
A2agegroups: Vaccine effectiveness by number of vaccine DOSES (segregated by variant period and 2 age groups)
Groups manually excluded:
- Cases before alpha rise, 60 years old or above, with more than one vaccine dose.
- All cases before alpha rise, younger than 60 years.
- Cases during alpha predominance, 60 years old or above, with three vaccine doses.
- All cases during alpha predominance, younger than 60 years.
- Cases during delta predominance, younger than 60 years, with three vaccine doses.
Groups automatically excluded:
- Those with upper vaccine effectiveness estimation interval above 100%.
- Those with lower vaccine effectiveness estimation interval below 0%.
- Those with vaccine effectiveness point-estimate above 100% or below 0%.
Vaccine effectiveness for preventing hospital admission. Data stratification by variant period and age group
|
Variant period
|
Age group
|
Vaccine doses
|
VE
|
VE lower CI limit
|
VE upper CI limit
|
p value
|
|
Before α
|
60 years or older
|
One dose
|
61.14784
|
67.79222
|
53.13274
|
0e+00
|
|
α
|
60 years or older
|
One dose
|
47.49288
|
53.71818
|
40.43022
|
0e+00
|
|
α
|
60 years or older
|
Two doses
|
77.73654
|
82.03578
|
72.40839
|
0e+00
|
|
Δ
|
59 years or younger
|
One dose
|
79.31538
|
81.88191
|
76.38529
|
0e+00
|
|
Δ
|
59 years or younger
|
Two doses
|
93.89672
|
94.59422
|
93.10921
|
0e+00
|
|
Δ
|
60 years or older
|
One dose
|
71.31803
|
76.04587
|
65.65704
|
0e+00
|
|
Δ
|
60 years or older
|
Two doses
|
85.52624
|
87.32563
|
83.47138
|
0e+00
|
|
Δ
|
60 years or older
|
Three doses
|
90.48374
|
92.88994
|
87.26322
|
0e+00
|
|
Ό
|
59 years or younger
|
One dose
|
60.87284
|
66.72872
|
53.98630
|
0e+00
|
|
Ό
|
59 years or younger
|
Two doses
|
77.70597
|
79.91589
|
75.25289
|
0e+00
|
|
Ό
|
59 years or younger
|
Three doses
|
87.07150
|
88.77266
|
85.11259
|
0e+00
|
|
Ό
|
60 years or older
|
One dose
|
45.38583
|
57.02870
|
30.58839
|
8e-07
|
|
Ό
|
60 years or older
|
Two doses
|
66.45363
|
70.44079
|
61.92865
|
0e+00
|
|
Ό
|
60 years or older
|
Three doses
|
87.58651
|
88.95113
|
86.05335
|
0e+00
|
Vaccine effectiveness for preventing ICU admission. Data stratification by variant period and age group
|
Variant period
|
Age group
|
Vaccine doses
|
VE
|
VE lower CI limit
|
VE upper CI limit
|
p value
|
|
Before α
|
60 years or older
|
One dose
|
84.96616
|
96.26098
|
39.551980
|
0.0076076
|
|
α
|
60 years or older
|
One dose
|
55.41500
|
69.08323
|
35.704067
|
0.0000153
|
|
Δ
|
59 years or younger
|
One dose
|
81.92263
|
87.33990
|
74.187313
|
0.0000000
|
|
Δ
|
59 years or younger
|
Two doses
|
94.09616
|
95.60461
|
92.070036
|
0.0000000
|
|
Δ
|
60 years or older
|
One dose
|
77.76422
|
84.78315
|
67.507723
|
0.0000000
|
|
Δ
|
60 years or older
|
Two doses
|
87.98747
|
90.86903
|
84.196550
|
0.0000000
|
|
Δ
|
60 years or older
|
Three doses
|
92.17169
|
97.57541
|
74.724599
|
0.0000205
|
|
Ό
|
59 years or younger
|
One dose
|
70.19916
|
81.51829
|
51.947633
|
0.0000007
|
|
Ό
|
59 years or younger
|
Two doses
|
87.54410
|
90.78673
|
83.160231
|
0.0000000
|
|
Ό
|
59 years or younger
|
Three doses
|
91.97721
|
94.77408
|
87.683470
|
0.0000000
|
|
Ό
|
60 years or older
|
One dose
|
50.92523
|
73.37503
|
9.546054
|
0.0225166
|
|
Ό
|
60 years or older
|
Two doses
|
76.67530
|
83.49634
|
67.035100
|
0.0000000
|
|
Ό
|
60 years or older
|
Three doses
|
89.36960
|
92.23762
|
85.441931
|
0.0000000
|
Vaccine effectiveness for preventing mortality. Data stratification by variant period and age group
|
Variant period
|
Age group
|
Vaccine doses
|
VE
|
VE lower CI limit
|
VE upper CI limit
|
p value
|
|
Before α
|
60 years or older
|
One dose
|
31.11038
|
44.27030
|
14.84290
|
0.0005701
|
|
α
|
60 years or older
|
One dose
|
54.39254
|
64.58453
|
41.26747
|
0.0000000
|
|
α
|
60 years or older
|
Two doses
|
64.28560
|
73.34156
|
52.15329
|
0.0000000
|
|
Δ
|
59 years or younger
|
One dose
|
72.99838
|
83.38801
|
56.11078
|
0.0000001
|
|
Δ
|
59 years or younger
|
Two doses
|
91.76459
|
94.55577
|
87.54240
|
0.0000000
|
|
Δ
|
60 years or older
|
One dose
|
63.58233
|
74.71181
|
47.55470
|
0.0000001
|
|
Δ
|
60 years or older
|
Two doses
|
75.66996
|
80.11153
|
70.23649
|
0.0000000
|
|
Δ
|
60 years or older
|
Three doses
|
83.79189
|
89.54634
|
74.86979
|
0.0000000
|
|
Ό
|
59 years or younger
|
One dose
|
71.77716
|
84.84386
|
47.44513
|
0.0000666
|
|
Ό
|
59 years or younger
|
Two doses
|
78.01560
|
84.38338
|
69.05133
|
0.0000000
|
|
Ό
|
59 years or younger
|
Three doses
|
78.36239
|
85.22217
|
68.31834
|
0.0000000
|
|
Ό
|
60 years or older
|
One dose
|
41.04742
|
61.19667
|
10.43534
|
0.0132698
|
|
Ό
|
60 years or older
|
Two doses
|
55.15372
|
62.80944
|
45.92207
|
0.0000000
|
|
Ό
|
60 years or older
|
Three doses
|
80.37265
|
83.33015
|
76.89043
|
0.0000000
|
A3agegroups: Vaccine effectiveness by number of vaccine DOSES (segregated by variant period and 3 age groups)
Groups manually excluded:
- Cases before alpha rise, 43 years old or above, with more than one vaccine dose.
- All cases before alpha rise, younger than 44 years.
- Cases during alpha predominance, 43 years old or above, with three vaccine doses.
- All cases during alpha predominance, younger than 44 years.
- Cases during delta predominance, younger than 44 years, with three vaccine doses.
Groups automatically excluded:
- Those with upper vaccine effectiveness estimation interval above 100%.
- Those with lower vaccine effectiveness estimation interval below 0%.
- Those with vaccine effectiveness point-estimate above 100% or below 0%.
Vaccine effectiveness for preventing hospital admission by number of vaccine doses. Data stratification by variant period and age group
|
Variant period
|
Age group
|
Vaccine doses
|
VE
|
VE lower CI limit
|
VE upper CI limit
|
p value
|
|
Before α
|
44-74 years old
|
One dose
|
74.65687
|
82.47848
|
63.343675
|
0.0000000
|
|
Before α
|
More than 74 years old
|
One dose
|
59.93374
|
67.40034
|
50.756989
|
0.0000000
|
|
Before α
|
More than 74 years old
|
Two doses
|
60.03341
|
83.50849
|
3.142419
|
0.0422896
|
|
α
|
44-74 years old
|
One dose
|
52.81839
|
58.78720
|
45.985132
|
0.0000000
|
|
α
|
44-74 years old
|
Two doses
|
85.76323
|
90.97832
|
77.533500
|
0.0000000
|
|
α
|
More than 74 years old
|
One dose
|
47.89951
|
58.00362
|
35.364420
|
0.0000000
|
|
α
|
More than 74 years old
|
Two doses
|
76.43133
|
81.52330
|
69.936067
|
0.0000000
|
|
Δ
|
12-43 years old
|
One dose
|
82.03461
|
85.22177
|
78.160081
|
0.0000000
|
|
Δ
|
12-43 years old
|
Two doses
|
94.30513
|
95.50867
|
92.779064
|
0.0000000
|
|
Ό
|
12-43 years old
|
One dose
|
58.59062
|
67.21535
|
47.696970
|
0.0000000
|
|
Ό
|
12-43 years old
|
Two doses
|
73.48598
|
77.18510
|
69.187098
|
0.0000000
|
|
Ό
|
12-43 years old
|
Three doses
|
87.06120
|
89.95501
|
83.333733
|
0.0000000
|
|
Ό
|
44-74 years old
|
One dose
|
60.66238
|
66.98587
|
53.127705
|
0.0000000
|
|
Ό
|
44-74 years old
|
Two doses
|
78.57669
|
80.77872
|
76.122392
|
0.0000000
|
|
Ό
|
44-74 years old
|
Three doses
|
89.36813
|
90.53368
|
88.059071
|
0.0000000
|
|
Ό
|
More than 74 years old
|
Two doses
|
52.21971
|
60.92115
|
41.580785
|
0.0000000
|
|
Ό
|
More than 74 years old
|
Three doses
|
85.44159
|
87.76404
|
82.678338
|
0.0000000
|
Vaccine effectiveness for preventing ICU admission by number of vaccine doses. Data stratification by variant period and age group
|
Variant period
|
Age group
|
Vaccine doses
|
VE
|
VE lower CI limit
|
VE upper CI limit
|
p value
|
|
Before α
|
44-74 years old
|
One dose
|
87.91814
|
96.98966
|
51.51006
|
0.0028747
|
|
α
|
44-74 years old
|
One dose
|
59.42297
|
71.52881
|
42.16977
|
0.0000006
|
|
α
|
44-74 years old
|
Two doses
|
93.66842
|
99.11400
|
54.75262
|
0.0059538
|
|
Δ
|
12-43 years old
|
One dose
|
79.07473
|
87.69342
|
64.42009
|
0.0000000
|
|
Δ
|
12-43 years old
|
Two doses
|
95.17959
|
97.67200
|
90.01873
|
0.0000000
|
|
Ό
|
12-43 years old
|
One dose
|
68.63077
|
86.00400
|
29.69213
|
0.0048701
|
|
Ό
|
12-43 years old
|
Two doses
|
83.41676
|
90.11089
|
72.19122
|
0.0000000
|
|
Ό
|
12-43 years old
|
Three doses
|
90.61880
|
96.28585
|
76.30498
|
0.0000006
|
|
Ό
|
44-74 years old
|
One dose
|
63.56674
|
76.30286
|
43.98553
|
0.0000042
|
|
Ό
|
44-74 years old
|
Two doses
|
85.43673
|
88.82212
|
81.02603
|
0.0000000
|
|
Ό
|
44-74 years old
|
Three doses
|
92.17958
|
94.09873
|
89.63631
|
0.0000000
|
|
Ό
|
More than 74 years old
|
Three doses
|
79.61809
|
90.61349
|
55.74266
|
0.0000581
|
Vaccine effectiveness for preventing mortality by number of vaccine doses. Data stratification by variant period and age group
|
Variant period
|
Age group
|
Vaccine doses
|
VE
|
VE lower CI limit
|
VE upper CI limit
|
p value
|
|
Before α
|
More than 74 years old
|
One dose
|
35.19017
|
48.09691
|
19.073913
|
0.0001293
|
|
α
|
44-74 years old
|
One dose
|
59.00690
|
73.26487
|
37.145074
|
0.0000433
|
|
α
|
More than 74 years old
|
One dose
|
49.24701
|
62.65964
|
31.016585
|
0.0000148
|
|
α
|
More than 74 years old
|
Two doses
|
66.16363
|
75.34012
|
53.572365
|
0.0000000
|
|
Δ
|
12-43 years old
|
One dose
|
66.15212
|
84.60216
|
25.594840
|
0.0070254
|
|
Δ
|
12-43 years old
|
Two doses
|
89.66099
|
96.06311
|
72.847861
|
0.0000041
|
|
Ό
|
12-43 years old
|
Two doses
|
68.35995
|
85.72822
|
29.855100
|
0.0046121
|
|
Ό
|
12-43 years old
|
Three doses
|
64.00066
|
86.02809
|
7.245857
|
0.0343679
|
|
Ό
|
44-74 years old
|
One dose
|
54.91916
|
70.52569
|
31.049022
|
0.0002381
|
|
Ό
|
44-74 years old
|
Two doses
|
71.23109
|
77.39830
|
63.381069
|
0.0000000
|
|
Ό
|
44-74 years old
|
Three doses
|
82.48221
|
86.20234
|
77.759053
|
0.0000000
|
|
Ό
|
More than 74 years old
|
One dose
|
54.97753
|
77.40004
|
10.308586
|
0.0232469
|
|
Ό
|
More than 74 years old
|
Two doses
|
50.61341
|
61.01896
|
37.430212
|
0.0000000
|
|
Ό
|
More than 74 years old
|
Three doses
|
79.91649
|
83.51614
|
75.530775
|
0.0000000
|
B2agegroups: Risk of infection by time since last EXPOSURE (segregated by variant period and 2 age groups)
Groups manually excluded:
- All cases before alpha rise, younger than 60 years.
- All cases during alpha predominance, younger than 60 years.
Groups automatically excluded:
- Those with OR point-estimate above 10.
Risk (Odds Ratio) for hospital admission by time since last exposure. Data stratification by variant period and age group
|
Variant period
|
Age group
|
Time past since last exposure
|
OR
|
OR lower CI limit
|
OR upper CI limit
|
p value
|
|
Before α
|
60 years or older
|
31-90 days
|
0.6437178
|
0.3724258
|
1.1126311
|
0.1146340
|
|
Before α
|
60 years or older
|
91-180 days
|
0.4749253
|
0.2446283
|
0.9220275
|
0.0278212
|
|
Before α
|
60 years or older
|
>180 days
|
1.9582409
|
0.8428938
|
4.5494549
|
0.1181533
|
|
α
|
60 years or older
|
31-90 days
|
0.6014149
|
0.4861629
|
0.7439890
|
0.0000028
|
|
α
|
60 years or older
|
91-180 days
|
0.3122486
|
0.1691432
|
0.5764299
|
0.0001983
|
|
α
|
60 years or older
|
>180 days
|
1.6395965
|
0.5661895
|
4.7480160
|
0.3620677
|
|
Δ
|
59 years or younger
|
31-90 days
|
0.5920725
|
0.4823859
|
0.7267000
|
0.0000005
|
|
Δ
|
59 years or younger
|
91-180 days
|
0.7452503
|
0.6027457
|
0.9214465
|
0.0066174
|
|
Δ
|
59 years or younger
|
>180 days
|
0.8061347
|
0.6177052
|
1.0520441
|
0.1126327
|
|
Δ
|
60 years or older
|
31-90 days
|
1.0617437
|
0.8519885
|
1.3231395
|
0.5936690
|
|
Δ
|
60 years or older
|
91-180 days
|
1.3013888
|
1.0517094
|
1.6103431
|
0.0153569
|
|
Δ
|
60 years or older
|
>180 days
|
1.3005974
|
1.0341021
|
1.6357704
|
0.0246652
|
|
Ό
|
59 years or younger
|
31-90 days
|
0.8518970
|
0.6688873
|
1.0849786
|
0.1939454
|
|
Ό
|
59 years or younger
|
91-180 days
|
1.4184641
|
1.1322271
|
1.7770644
|
0.0023667
|
|
Ό
|
59 years or younger
|
>180 days
|
1.5184786
|
1.2248707
|
1.8824660
|
0.0001389
|
|
Ό
|
60 years or older
|
31-90 days
|
0.9441856
|
0.7900667
|
1.1283686
|
0.5276074
|
|
Ό
|
60 years or older
|
91-180 days
|
1.0893178
|
0.9106450
|
1.3030470
|
0.3493014
|
|
Ό
|
60 years or older
|
>180 days
|
2.6676291
|
2.2236244
|
3.2002909
|
0.0000000
|
Risk (Odds Ratio) for ICU admission by time since last exposure. Data stratification by variant period and age group
|
Variant period
|
Age group
|
Time past since last exposure
|
OR
|
OR lower CI limit
|
OR upper CI limit
|
p value
|
|
α
|
60 years or older
|
31-90 days
|
0.2731906
|
0.0825713
|
0.9038624
|
0.0335418
|
|
Δ
|
59 years or younger
|
31-90 days
|
0.4928607
|
0.2901304
|
0.8372500
|
0.0088710
|
|
Δ
|
59 years or younger
|
91-180 days
|
0.7208709
|
0.4197401
|
1.2380397
|
0.2355719
|
|
Δ
|
59 years or younger
|
>180 days
|
0.7184068
|
0.3528893
|
1.4625219
|
0.3618621
|
|
Δ
|
60 years or older
|
31-90 days
|
1.1383532
|
0.6364659
|
2.0360056
|
0.6622330
|
|
Δ
|
60 years or older
|
91-180 days
|
1.2299873
|
0.6860624
|
2.2051475
|
0.4870707
|
|
Δ
|
60 years or older
|
>180 days
|
1.0927812
|
0.5520587
|
2.1631227
|
0.7989732
|
|
Ό
|
59 years or younger
|
31-90 days
|
0.8102164
|
0.3538493
|
1.8551701
|
0.6185489
|
|
Ό
|
59 years or younger
|
91-180 days
|
1.3093824
|
0.6038570
|
2.8392189
|
0.4948556
|
|
Ό
|
59 years or younger
|
>180 days
|
1.4628902
|
0.7068779
|
3.0274645
|
0.3052959
|
|
Ό
|
60 years or older
|
31-90 days
|
0.7860889
|
0.4453056
|
1.3876670
|
0.4065011
|
|
Ό
|
60 years or older
|
91-180 days
|
1.0108652
|
0.5680064
|
1.7990086
|
0.9706888
|
|
Ό
|
60 years or older
|
>180 days
|
1.9929331
|
1.1281882
|
3.5204965
|
0.0175286
|
Risk (Odds Ratio) for mortality by time since last exposure. Data stratification by variant period and age group
|
Variant period
|
Age group
|
Time past since last exposure
|
OR
|
OR lower CI limit
|
OR upper CI limit
|
p value
|
|
Before α
|
60 years or older
|
31-90 days
|
0.5754715
|
0.3083602
|
1.073963
|
0.0825975
|
|
Before α
|
60 years or older
|
91-180 days
|
0.6839947
|
0.3327354
|
1.406069
|
0.3015897
|
|
Before α
|
60 years or older
|
>180 days
|
1.8403495
|
0.6087715
|
5.563477
|
0.2798518
|
|
α
|
60 years or older
|
31-90 days
|
0.8910350
|
0.6354779
|
1.249364
|
0.5034994
|
|
α
|
60 years or older
|
91-180 days
|
1.8918025
|
1.0254855
|
3.489973
|
0.0412993
|
|
Δ
|
59 years or younger
|
31-90 days
|
0.7099541
|
0.3156302
|
1.596915
|
0.4075345
|
|
Δ
|
59 years or younger
|
91-180 days
|
1.0495518
|
0.4603957
|
2.392635
|
0.9084196
|
|
Δ
|
59 years or younger
|
>180 days
|
1.1888666
|
0.4404642
|
3.208896
|
0.7327346
|
|
Δ
|
60 years or older
|
31-90 days
|
1.7819542
|
1.0548063
|
3.010374
|
0.0308187
|
|
Δ
|
60 years or older
|
91-180 days
|
2.1796219
|
1.3202271
|
3.598435
|
0.0023190
|
|
Δ
|
60 years or older
|
>180 days
|
2.4461665
|
1.4618114
|
4.093367
|
0.0006608
|
|
Ό
|
59 years or younger
|
31-90 days
|
0.7231443
|
0.3857891
|
1.355502
|
0.3119510
|
|
Ό
|
59 years or younger
|
91-180 days
|
1.1708832
|
0.6454737
|
2.123971
|
0.6036191
|
|
Ό
|
59 years or younger
|
>180 days
|
1.0995110
|
0.6324125
|
1.911607
|
0.7367366
|
|
Ό
|
60 years or older
|
31-90 days
|
1.0445342
|
0.7538068
|
1.447389
|
0.7934729
|
|
Ό
|
60 years or older
|
91-180 days
|
1.3276935
|
0.9596694
|
1.836851
|
0.0870064
|
|
Ό
|
60 years or older
|
>180 days
|
2.5053176
|
1.7967684
|
3.493281
|
0.0000001
|
B3agegroups: Risk of infection by time since last EXPOSURE (segregated by variant period and 3 age groups)
Groups manually excluded:
- All cases before alpha rise, younger than 44 years.
- All cases during alpha predominance, younger than 44 years.
Groups automatically excluded:
- Those with OR point-estimate above 10.
Risk (Odds Ratio) for hospital admission by time since last exposure. Data stratification by variant period and age group
|
Variant period
|
Age group
|
Time past since last exposure
|
OR
|
OR lower CI limit
|
OR upper CI limit
|
p value
|
|
Before α
|
44-74 years old
|
31-90 days
|
1.3417626
|
0.4867521
|
3.6986522
|
0.5698642
|
|
Before α
|
44-74 years old
|
91-180 days
|
1.2481989
|
0.5821725
|
2.6761834
|
0.5688610
|
|
Before α
|
44-74 years old
|
>180 days
|
3.3544546
|
1.3109380
|
8.5834463
|
0.0115779
|
|
Before α
|
More than 74 years old
|
31-90 days
|
0.5886328
|
0.3160730
|
1.0962295
|
0.0948452
|
|
Before α
|
More than 74 years old
|
91-180 days
|
0.5120179
|
0.2331254
|
1.1245547
|
0.0954072
|
|
Before α
|
More than 74 years old
|
>180 days
|
1.2370175
|
0.3376567
|
4.5318584
|
0.7481550
|
|
α
|
44-74 years old
|
31-90 days
|
0.4365597
|
0.3221555
|
0.5915912
|
0.0000001
|
|
α
|
44-74 years old
|
91-180 days
|
0.2969258
|
0.1587976
|
0.5552031
|
0.0001431
|
|
α
|
44-74 years old
|
>180 days
|
2.1219411
|
1.0026446
|
4.4907576
|
0.0491983
|
|
α
|
More than 74 years old
|
31-90 days
|
0.7269947
|
0.5551424
|
0.9520465
|
0.0204987
|
|
α
|
More than 74 years old
|
91-180 days
|
0.3296005
|
0.1463279
|
0.7424184
|
0.0073875
|
|
α
|
More than 74 years old
|
>180 days
|
2.1116569
|
0.4642774
|
9.6043774
|
0.3334581
|
|
Δ
|
12-43 years old
|
31-90 days
|
0.6175846
|
0.4401699
|
0.8665082
|
0.0052836
|
|
Δ
|
12-43 years old
|
91-180 days
|
0.5531368
|
0.3899947
|
0.7845241
|
0.0008970
|
|
Δ
|
12-43 years old
|
>180 days
|
0.5972231
|
0.3688962
|
0.9668721
|
0.0359920
|
|
Δ
|
44-74 years old
|
31-90 days
|
0.8449076
|
0.7012333
|
1.0180190
|
0.0763663
|
|
Δ
|
44-74 years old
|
91-180 days
|
1.1059908
|
0.9157461
|
1.3357585
|
0.2955385
|
|
Δ
|
44-74 years old
|
>180 days
|
1.0982503
|
0.8805256
|
1.3698111
|
0.4057917
|
|
Δ
|
More than 74 years old
|
31-90 days
|
1.2169635
|
0.7539365
|
1.9643565
|
0.4215221
|
|
Δ
|
More than 74 years old
|
91-180 days
|
1.4655076
|
0.9536648
|
2.2520621
|
0.0812398
|
|
Δ
|
More than 74 years old
|
>180 days
|
1.4717564
|
0.9470950
|
2.2870640
|
0.0857449
|
|
Ό
|
12-43 years old
|
31-90 days
|
0.8718432
|
0.5768263
|
1.3177460
|
0.5152136
|
|
Ό
|
12-43 years old
|
91-180 days
|
1.1299112
|
0.7793663
|
1.6381249
|
0.5192296
|
|
Ό
|
12-43 years old
|
>180 days
|
1.4129740
|
0.9744212
|
2.0489041
|
0.0682582
|
|
Ό
|
44-74 years old
|
31-90 days
|
0.8946381
|
0.7468334
|
1.0716947
|
0.2268829
|
|
Ό
|
44-74 years old
|
91-180 days
|
1.5567348
|
1.2997002
|
1.8646019
|
0.0000015
|
|
Ό
|
44-74 years old
|
>180 days
|
2.1436473
|
1.8026607
|
2.5491340
|
0.0000000
|
|
Ό
|
More than 74 years old
|
31-90 days
|
0.7077836
|
0.5232503
|
0.9573959
|
0.0249322
|
|
Ό
|
More than 74 years old
|
91-180 days
|
0.6659138
|
0.4928197
|
0.8998041
|
0.0081114
|
|
Ό
|
More than 74 years old
|
>180 days
|
1.8662871
|
1.3639611
|
2.5536121
|
0.0000961
|
Risk (Odds Ratio) for ICU admission by time since last exposure. Data stratification by variant period and age group
|
Variant period
|
Age group
|
Time past since last exposure
|
OR
|
OR lower CI limit
|
OR upper CI limit
|
p value
|
|
α
|
44-74 years old
|
31-90 days
|
0.3730192
|
0.1436272
|
0.9687814
|
0.0428575
|
|
α
|
44-74 years old
|
91-180 days
|
0.2804386
|
0.0378329
|
2.0787690
|
0.2135092
|
|
Δ
|
12-43 years old
|
31-90 days
|
0.4587120
|
0.1690900
|
1.2444064
|
0.1258835
|
|
Δ
|
12-43 years old
|
91-180 days
|
0.4630894
|
0.1705886
|
1.2571284
|
0.1308226
|
|
Δ
|
12-43 years old
|
>180 days
|
1.3711907
|
0.5047431
|
3.7249920
|
0.5358498
|
|
Δ
|
44-74 years old
|
31-90 days
|
0.8842901
|
0.5680668
|
1.3765442
|
0.5860189
|
|
Δ
|
44-74 years old
|
91-180 days
|
1.0840728
|
0.6908851
|
1.7010263
|
0.7254379
|
|
Δ
|
44-74 years old
|
>180 days
|
0.7106568
|
0.3936509
|
1.2829464
|
0.2570969
|
|
Ό
|
12-43 years old
|
31-90 days
|
0.9601424
|
0.1801695
|
5.1167024
|
0.9619991
|
|
Ό
|
12-43 years old
|
91-180 days
|
1.1500114
|
0.2582354
|
5.1213965
|
0.8544782
|
|
Ό
|
12-43 years old
|
>180 days
|
1.5516136
|
0.3514918
|
6.8493908
|
0.5620137
|
|
Ό
|
44-74 years old
|
31-90 days
|
0.6476484
|
0.3906258
|
1.0737859
|
0.0921833
|
|
Ό
|
44-74 years old
|
91-180 days
|
1.0924911
|
0.6619090
|
1.8031735
|
0.7293382
|
|
Ό
|
44-74 years old
|
>180 days
|
1.4832094
|
0.9245919
|
2.3793310
|
0.1020868
|
Risk (Odds Ratio) for mortality by time since last exposure. Data stratification by variant period and age group
|
Variant period
|
Age group
|
Time past since last exposure
|
OR
|
OR lower CI limit
|
OR upper CI limit
|
p value
|
|
Before α
|
44-74 years old
|
31-90 days
|
0.9778423
|
0.1979489
|
4.830415
|
0.9780661
|
|
Before α
|
44-74 years old
|
91-180 days
|
1.0060912
|
0.2971177
|
3.406796
|
0.9922140
|
|
Before α
|
44-74 years old
|
>180 days
|
1.5841863
|
0.3000588
|
8.363848
|
0.5878529
|
|
Before α
|
More than 74 years old
|
31-90 days
|
0.6058782
|
0.3162118
|
1.160894
|
0.1309694
|
|
Before α
|
More than 74 years old
|
91-180 days
|
0.7145617
|
0.3216742
|
1.587316
|
0.4091874
|
|
Before α
|
More than 74 years old
|
>180 days
|
2.0333950
|
0.5514722
|
7.497558
|
0.2864210
|
|
α
|
44-74 years old
|
31-90 days
|
1.8730853
|
0.8995363
|
3.900286
|
0.0935343
|
|
α
|
More than 74 years old
|
31-90 days
|
0.7771836
|
0.5389807
|
1.120661
|
0.1770429
|
|
α
|
More than 74 years old
|
91-180 days
|
0.9911518
|
0.4472283
|
2.196600
|
0.9825363
|
|
Δ
|
12-43 years old
|
31-90 days
|
0.8290169
|
0.2047105
|
3.357274
|
0.7927276
|
|
Δ
|
12-43 years old
|
91-180 days
|
0.6075313
|
0.1342087
|
2.750152
|
0.5177280
|
|
Δ
|
12-43 years old
|
>180 days
|
1.2925251
|
0.2351807
|
7.103562
|
0.7678851
|
|
Δ
|
44-74 years old
|
31-90 days
|
1.8076177
|
0.9349925
|
3.494661
|
0.0783875
|
|
Δ
|
44-74 years old
|
91-180 days
|
2.3457999
|
1.2154008
|
4.527541
|
0.0110403
|
|
Δ
|
44-74 years old
|
>180 days
|
2.2590263
|
1.1095672
|
4.599271
|
0.0246665
|
|
Δ
|
More than 74 years old
|
31-90 days
|
1.2496784
|
0.6109556
|
2.556153
|
0.5415632
|
|
Δ
|
More than 74 years old
|
91-180 days
|
1.6375158
|
0.8655520
|
3.097974
|
0.1294946
|
|
Δ
|
More than 74 years old
|
>180 days
|
1.8769210
|
0.9810567
|
3.590855
|
0.0571469
|
|
Ό
|
12-43 years old
|
31-90 days
|
0.3818044
|
0.0519035
|
2.808569
|
0.3443067
|
|
Ό
|
12-43 years old
|
91-180 days
|
1.1578409
|
0.2532281
|
5.294023
|
0.8501123
|
|
Ό
|
12-43 years old
|
>180 days
|
1.1953700
|
0.2595503
|
5.505327
|
0.8188566
|
|
Ό
|
44-74 years old
|
31-90 days
|
0.8012195
|
0.5432576
|
1.181673
|
0.2636026
|
|
Ό
|
44-74 years old
|
91-180 days
|
1.6077996
|
1.0987756
|
2.352636
|
0.0144870
|
|
Ό
|
44-74 years old
|
>180 days
|
1.9051984
|
1.3081019
|
2.774846
|
0.0007796
|
|
Ό
|
More than 74 years old
|
31-90 days
|
0.9501727
|
0.6040302
|
1.494674
|
0.8249901
|
|
Ό
|
More than 74 years old
|
91-180 days
|
1.0180481
|
0.6490628
|
1.596798
|
0.9379175
|
|
Ό
|
More than 74 years old
|
>180 days
|
2.0374755
|
1.2797117
|
3.243939
|
0.0027055
|
C2agegroups: Risk of infection by time since last VACCINATION (segregated by variant period and 2 age groups)
Groups manually excluded:
- All cases before alpha rise, younger than 60 years.
- All cases during alpha predominance, younger than 60 years.
Groups automatically excluded:
- Those with infinite OR upper CI limits.
Risk (Odds Ratio) for hospital admission by time since last vaccine dose. Data stratification by variant period and age group
|
Variant period
|
Age group
|
Time past since last vaccine dose (days)
|
Odds Ratio (OR)
|
OR lower CI limit
|
OR upper CI limit
|
p value
|
|
Before α
|
60 years or older
|
31-90
|
0.6191601
|
0.3534733
|
1.0845493
|
0.0937039
|
|
α
|
60 years or older
|
31-90
|
0.7668429
|
0.6119591
|
0.9609271
|
0.0210992
|
|
α
|
60 years or older
|
91-180
|
0.4982216
|
0.2073486
|
1.1971376
|
0.1193100
|
|
Δ
|
59 years or younger
|
31-90
|
0.8311099
|
0.6727198
|
1.0267927
|
0.0863695
|
|
Δ
|
59 years or younger
|
91-180
|
1.1493441
|
0.9134611
|
1.4461392
|
0.2349714
|
|
Δ
|
59 years or younger
|
>180
|
1.2783776
|
0.9552152
|
1.7108704
|
0.0985758
|
|
Δ
|
60 years or older
|
31-90
|
0.9159565
|
0.7279330
|
1.1525459
|
0.4539406
|
|
Δ
|
60 years or older
|
91-180
|
1.1652447
|
0.9228118
|
1.4713674
|
0.1987938
|
|
Δ
|
60 years or older
|
>180
|
1.1885405
|
0.9264734
|
1.5247372
|
0.1741270
|
|
Ό
|
59 years or younger
|
31-90
|
0.8683954
|
0.6813151
|
1.1068457
|
0.2543252
|
|
Ό
|
59 years or younger
|
91-180
|
1.0475157
|
0.8154248
|
1.3456655
|
0.7164125
|
|
Ό
|
59 years or younger
|
>180
|
1.0168368
|
0.7828651
|
1.3207346
|
0.9004074
|
|
Ό
|
60 years or older
|
31-90
|
0.9397163
|
0.7853918
|
1.1243646
|
0.4969409
|
|
Ό
|
60 years or older
|
91-180
|
1.0326586
|
0.8624031
|
1.2365260
|
0.7266406
|
|
Ό
|
60 years or older
|
>180
|
1.3685276
|
1.0999456
|
1.7026914
|
0.0048844
|
Risk (Odds Ratio) for ICU admission by time since last vaccine dose. Data stratification by variant period and age group
|
Variant period
|
Age group
|
Time past since last vaccine dose (days)
|
Odds Ratio (OR)
|
OR lower CI limit
|
OR upper CI limit
|
p value
|
|
α
|
60 years or older
|
31-90
|
0.2967046
|
0.0895402
|
0.9831742
|
0.0468422
|
|
Δ
|
59 years or younger
|
31-90
|
0.6279838
|
0.3651827
|
1.0799081
|
0.0925635
|
|
Δ
|
59 years or younger
|
91-180
|
0.9867680
|
0.5548167
|
1.7550143
|
0.9638355
|
|
Δ
|
59 years or younger
|
>180
|
0.7652409
|
0.3304396
|
1.7721653
|
0.5323128
|
|
Δ
|
60 years or older
|
31-90
|
0.9838494
|
0.5432063
|
1.7819373
|
0.9571525
|
|
Δ
|
60 years or older
|
91-180
|
1.1041162
|
0.6049163
|
2.0152745
|
0.7469816
|
|
Δ
|
60 years or older
|
>180
|
1.0894317
|
0.5445839
|
2.1793914
|
0.8086877
|
|
Ό
|
59 years or younger
|
31-90
|
0.8350691
|
0.3645037
|
1.9131233
|
0.6700016
|
|
Ό
|
59 years or younger
|
91-180
|
1.0694401
|
0.4551860
|
2.5126041
|
0.8775745
|
|
Ό
|
59 years or younger
|
>180
|
1.1463601
|
0.4676562
|
2.8100591
|
0.7652571
|
|
Ό
|
60 years or older
|
31-90
|
0.7804089
|
0.4419362
|
1.3781130
|
0.3927943
|
|
Ό
|
60 years or older
|
91-180
|
0.9029340
|
0.5051940
|
1.6138154
|
0.7303794
|
|
Ό
|
60 years or older
|
>180
|
1.0929184
|
0.5465981
|
2.1852813
|
0.8015578
|
Risk (Odds Ratio) for mortality by time since last vaccine dose. Data stratification by variant period and age group
|
Variant period
|
Age group
|
Time past since last vaccine dose (days)
|
Odds Ratio (OR)
|
OR lower CI limit
|
OR upper CI limit
|
p value
|
|
Before α
|
60 years or older
|
31-90
|
0.5813952
|
0.3111825
|
1.086245
|
0.0890259
|
|
α
|
60 years or older
|
31-90
|
0.9733030
|
0.6658600
|
1.422700
|
0.8888889
|
|
α
|
60 years or older
|
91-180
|
1.1222993
|
0.4396351
|
2.865003
|
0.8093260
|
|
Δ
|
59 years or younger
|
31-90
|
0.8770853
|
0.3845361
|
2.000537
|
0.7552373
|
|
Δ
|
59 years or younger
|
91-180
|
1.5732673
|
0.6674115
|
3.708611
|
0.3003145
|
|
Δ
|
59 years or younger
|
>180
|
1.7410989
|
0.6040233
|
5.018723
|
0.3046031
|
|
Δ
|
60 years or older
|
31-90
|
1.7960953
|
1.0326670
|
3.123910
|
0.0380983
|
|
Δ
|
60 years or older
|
91-180
|
2.2892789
|
1.2989152
|
4.034750
|
0.0041771
|
|
Δ
|
60 years or older
|
>180
|
2.6075120
|
1.4597539
|
4.657716
|
0.0012040
|
|
Ό
|
59 years or younger
|
31-90
|
0.7325618
|
0.3910901
|
1.372182
|
0.3311146
|
|
Ό
|
59 years or younger
|
91-180
|
1.4139966
|
0.7522351
|
2.657927
|
0.2820131
|
|
Ό
|
59 years or younger
|
>180
|
1.7351826
|
0.8251530
|
3.648849
|
0.1461687
|
|
Ό
|
60 years or older
|
31-90
|
1.0617051
|
0.7652375
|
1.473030
|
0.7200468
|
|
Ό
|
60 years or older
|
91-180
|
1.3131836
|
0.9483961
|
1.818282
|
0.1008242
|
|
Ό
|
60 years or older
|
>180
|
1.4188347
|
0.9657908
|
2.084398
|
0.0746517
|
C3agegroups: Risk of infection by time since last VACCINATION (segregated by variant period and 3 age groups)
Groups manually excluded:
- All cases before alpha rise, younger than 44 years.
- All cases during alpha predominance, younger than 44 years.
Groups automatically excluded:
- Those with infinite OR upper CI limits.
Risk (Odds Ratio) for hospital admission by time since last vaccine dose. Data stratification by variant period and age group
|
Variant period
|
Age group
|
Time past since last vaccine dose (days)
|
Odds Ratio (OR)
|
OR lower CI limit
|
OR upper CI limit
|
p value
|
|
Before α
|
44-74 years old
|
31-90
|
1.1641108
|
0.3863863
|
3.5072515
|
0.7871218
|
|
Before α
|
More than 74 years old
|
31-90
|
0.5976633
|
0.3206798
|
1.1138882
|
0.1051423
|
|
α
|
44-74 years old
|
31-90
|
0.4713985
|
0.3463962
|
0.6415098
|
0.0000017
|
|
α
|
44-74 years old
|
91-180
|
0.3583738
|
0.1074567
|
1.1951952
|
0.0949558
|
|
α
|
More than 74 years old
|
31-90
|
1.0534053
|
0.7719556
|
1.4374697
|
0.7428817
|
|
α
|
More than 74 years old
|
91-180
|
0.4560525
|
0.1563102
|
1.3305845
|
0.1506728
|
|
Δ
|
12-43 years old
|
31-90
|
0.8511855
|
0.5972732
|
1.2130408
|
0.3726900
|
|
Δ
|
12-43 years old
|
91-180
|
0.8737990
|
0.5750722
|
1.3277023
|
0.5273736
|
|
Δ
|
12-43 years old
|
>180
|
0.8691634
|
0.4829603
|
1.5641971
|
0.6399806
|
|
Δ
|
44-74 years old
|
31-90
|
0.8124929
|
0.6721420
|
0.9821506
|
0.0318642
|
|
Δ
|
44-74 years old
|
91-180
|
1.1428475
|
0.9409943
|
1.3880003
|
0.1781085
|
|
Δ
|
44-74 years old
|
>180
|
1.2253853
|
0.9765036
|
1.5376996
|
0.0793108
|
|
Δ
|
More than 74 years old
|
31-90
|
0.9446863
|
0.5457193
|
1.6353321
|
0.8389489
|
|
Δ
|
More than 74 years old
|
91-180
|
0.9527667
|
0.5307597
|
1.7103113
|
0.8712339
|
|
Δ
|
More than 74 years old
|
>180
|
0.9484137
|
0.5235949
|
1.7179093
|
0.8612837
|
|
Ό
|
12-43 years old
|
31-90
|
0.9355820
|
0.6172089
|
1.4181807
|
0.7537124
|
|
Ό
|
12-43 years old
|
91-180
|
0.6221893
|
0.4123589
|
0.9387926
|
0.0237651
|
|
Ό
|
12-43 years old
|
>180
|
0.7040552
|
0.4624909
|
1.0717913
|
0.1017140
|
|
Ό
|
44-74 years old
|
31-90
|
0.8841910
|
0.7375847
|
1.0599374
|
0.1833034
|
|
Ό
|
44-74 years old
|
91-180
|
1.3657200
|
1.1351350
|
1.6431449
|
0.0009554
|
|
Ό
|
44-74 years old
|
>180
|
1.4662680
|
1.1859134
|
1.8128997
|
0.0004080
|
|
Ό
|
More than 74 years old
|
31-90
|
0.8162429
|
0.5979109
|
1.1143006
|
0.2010748
|
|
Ό
|
More than 74 years old
|
91-180
|
0.7622188
|
0.5588841
|
1.0395315
|
0.0863320
|
|
Ό
|
More than 74 years old
|
>180
|
0.6191223
|
0.4170057
|
0.9192020
|
0.0174168
|
Risk (Odds Ratio) for ICU admission by time since last vaccine dose. Data stratification by variant period and age group
|
Variant period
|
Age group
|
Time past since last vaccine dose (days)
|
Odds Ratio (OR)
|
OR lower CI limit
|
OR upper CI limit
|
p value
|
|
α
|
44-74 years old
|
31-90
|
0.4124558
|
0.1584464
|
1.073674
|
0.0696264
|
|
Δ
|
12-43 years old
|
31-90
|
0.6807539
|
0.2451903
|
1.890066
|
0.4604595
|
|
Δ
|
12-43 years old
|
91-180
|
0.6642545
|
0.1904549
|
2.316738
|
0.5209860
|
|
Δ
|
12-43 years old
|
>180
|
1.5638172
|
0.3927094
|
6.227313
|
0.5259451
|
|
Δ
|
44-74 years old
|
31-90
|
0.8570474
|
0.5479202
|
1.340579
|
0.4991394
|
|
Δ
|
44-74 years old
|
91-180
|
1.1136824
|
0.7020267
|
1.766726
|
0.6474406
|
|
Δ
|
44-74 years old
|
>180
|
0.7981022
|
0.4381812
|
1.453661
|
0.4610206
|
|
Ό
|
12-43 years old
|
31-90
|
1.0326302
|
0.1938182
|
5.501678
|
0.9699923
|
|
Ό
|
12-43 years old
|
91-180
|
0.7921722
|
0.1533207
|
4.092968
|
0.7809745
|
|
Ό
|
12-43 years old
|
>180
|
0.9945550
|
0.1862147
|
5.311823
|
0.9949037
|
|
Ό
|
44-74 years old
|
31-90
|
0.6464117
|
0.3895391
|
1.072673
|
0.0913190
|
|
Ό
|
44-74 years old
|
91-180
|
0.9141244
|
0.5460034
|
1.530436
|
0.7327369
|
|
Ό
|
44-74 years old
|
>180
|
0.9189078
|
0.5106726
|
1.653489
|
0.7778258
|
Risk (Odds Ratio) for mortality by time since last vaccine dose. Data stratification by variant period and age group
|
Variant period
|
Age group
|
Time past since last vaccine dose (days)
|
Odds Ratio (OR)
|
OR lower CI limit
|
OR upper CI limit
|
p value
|
|
Before α
|
44-74 years old
|
31-90
|
1.2254969
|
0.2528613
|
5.939394
|
0.8006346
|
|
Before α
|
More than 74 years old
|
31-90
|
0.6059954
|
0.3159965
|
1.162135
|
0.1316365
|
|
α
|
44-74 years old
|
31-90
|
1.7696749
|
0.8442576
|
3.709471
|
0.1306309
|
|
α
|
44-74 years old
|
91-180
|
2.2930179
|
0.4588810
|
11.458159
|
0.3120216
|
|
α
|
More than 74 years old
|
31-90
|
0.8987583
|
0.5914991
|
1.365626
|
0.6170213
|
|
α
|
More than 74 years old
|
91-180
|
0.7201131
|
0.2382836
|
2.176242
|
0.5606353
|
|
Δ
|
12-43 years old
|
31-90
|
1.2294426
|
0.2945619
|
5.131448
|
0.7769119
|
|
Δ
|
12-43 years old
|
91-180
|
1.2546764
|
0.2433992
|
6.467619
|
0.7862733
|
|
Δ
|
12-43 years old
|
>180
|
3.0229076
|
0.4782339
|
19.107743
|
0.2396483
|
|
Δ
|
44-74 years old
|
31-90
|
1.9516899
|
0.9912165
|
3.842847
|
0.0530588
|
|
Δ
|
44-74 years old
|
91-180
|
2.7115408
|
1.3638608
|
5.390912
|
0.0044407
|
|
Δ
|
44-74 years old
|
>180
|
2.7230556
|
1.2980901
|
5.712263
|
0.0080452
|
|
Δ
|
More than 74 years old
|
31-90
|
1.1405369
|
0.5212046
|
2.495804
|
0.7420690
|
|
Δ
|
More than 74 years old
|
91-180
|
1.3647721
|
0.5884549
|
3.165243
|
0.4687267
|
|
Δ
|
More than 74 years old
|
>180
|
1.5755201
|
0.6727735
|
3.689598
|
0.2950750
|
|
Ό
|
12-43 years old
|
31-90
|
0.3617209
|
0.0498081
|
2.626923
|
0.3147891
|
|
Ό
|
12-43 years old
|
91-180
|
2.3384126
|
0.4562257
|
11.985676
|
0.3083062
|
|
Ό
|
12-43 years old
|
>180
|
3.1701578
|
0.5273328
|
19.057983
|
0.2074076
|
|
Ό
|
44-74 years old
|
31-90
|
0.8020340
|
0.5436017
|
1.183327
|
0.2662691
|
|
Ό
|
44-74 years old
|
91-180
|
1.5574123
|
1.0597252
|
2.288832
|
0.0241165
|
|
Ό
|
44-74 years old
|
>180
|
1.7731879
|
1.1142972
|
2.821685
|
0.0156678
|
|
Ό
|
More than 74 years old
|
31-90
|
1.0395303
|
0.6563391
|
1.646441
|
0.8687537
|
|
Ό
|
More than 74 years old
|
91-180
|
1.1047557
|
0.6994681
|
1.744876
|
0.6692270
|
|
Ό
|
More than 74 years old
|
>180
|
0.8563865
|
0.4958275
|
1.479139
|
0.5781989
|
General analysis of the infection risk by time since last VACCINATION
Risk (Odds Ratio) for the outcomes of interest by time since last vaccine dose.
|
Outcome of interest
|
Time past since last vaccine dose
|
OR
|
OR lower CI limit
|
OR upper CI limit
|
p value
|
|
Hospital admission
|
Last vaccine received 31-90 days ago days
|
0.8387315
|
0.7780473
|
0.9041489
|
0.0000044
|
|
Hospital admission
|
Last vaccine received 91-180 days ago days
|
1.1258666
|
1.0443219
|
1.2137785
|
0.0019982
|
|
Hospital admission
|
Last vaccine received more than 180 days ago days
|
1.2846880
|
1.1796107
|
1.3991255
|
0.0000000
|
|
ICU admission
|
Last vaccine received 31-90 days ago days
|
0.8205685
|
0.6472310
|
1.0403283
|
0.1023831
|
|
ICU admission
|
Last vaccine received 91-180 days ago days
|
0.9997472
|
0.7830870
|
1.2763516
|
0.9983812
|
|
ICU admission
|
Last vaccine received more than 180 days ago days
|
0.9827776
|
0.7475061
|
1.2920989
|
0.9009739
|
|
30-days mortality
|
Last vaccine received 31-90 days ago days
|
0.8480470
|
0.7251295
|
0.9918002
|
0.0391105
|
|
30-days mortality
|
Last vaccine received 91-180 days ago days
|
0.9951837
|
0.8509578
|
1.1638539
|
0.9518060
|
|
30-days mortality
|
Last vaccine received more than 180 days ago days
|
1.1849971
|
0.9925980
|
1.4146896
|
0.0604121
|
General analysis of the infection risk by time since last VACCINATION (2 age groups)
Risk (Odds Ratio) for the outcomes of interest by time since last vaccine dose.
|
Outcome of interest
|
Age group
|
Time past since last vaccine dose
|
OR
|
OR lower CI limit
|
OR upper CI limit
|
p value
|
|
Hospital admission
|
Younger than 60 years
|
Last vaccine received 31-90 days ago
|
0.9887834
|
0.8638931
|
1.1317287
|
0.8699409
|
|
Hospital admission
|
Younger than 60 years
|
Last vaccine received 91-180 days ago
|
0.9868199
|
0.8601961
|
1.1320831
|
0.8498104
|
|
Hospital admission
|
Younger than 60 years
|
Last vaccine received more than 180 days ago
|
1.3696667
|
1.1873923
|
1.5799216
|
0.0000158
|
|
Hospital admission
|
60 years or older
|
Last vaccine received 31-90 days ago
|
0.8421596
|
0.7680473
|
0.9234234
|
0.0002572
|
|
Hospital admission
|
60 years or older
|
Last vaccine received 91-180 days ago
|
1.2024841
|
1.0958177
|
1.3195335
|
0.0001000
|
|
Hospital admission
|
60 years or older
|
Last vaccine received more than 180 days ago
|
1.5509980
|
1.3909015
|
1.7295219
|
0.0000000
|
|
ICU admission
|
Younger than 60 years
|
Last vaccine received 31-90 days ago
|
1.0635170
|
0.7117514
|
1.5891339
|
0.7637692
|
|
ICU admission
|
Younger than 60 years
|
Last vaccine received 91-180 days ago
|
0.8546412
|
0.5622014
|
1.2991991
|
0.4623035
|
|
ICU admission
|
Younger than 60 years
|
Last vaccine received more than 180 days ago
|
1.0677818
|
0.6905793
|
1.6510168
|
0.7680328
|
|
ICU admission
|
60 years or older
|
Last vaccine received 31-90 days ago
|
0.9034648
|
0.6656695
|
1.2262070
|
0.5147761
|
|
ICU admission
|
60 years or older
|
Last vaccine received 91-180 days ago
|
0.8975107
|
0.6522542
|
1.2349870
|
0.5067127
|
|
ICU admission
|
60 years or older
|
Last vaccine received more than 180 days ago
|
1.0908050
|
0.7602525
|
1.5650795
|
0.6370247
|
|
30-days mortality
|
Younger than 60 years
|
Last vaccine received 31-90 days ago
|
0.9586926
|
0.6163494
|
1.4911861
|
0.8515326
|
|
30-days mortality
|
Younger than 60 years
|
Last vaccine received 91-180 days ago
|
0.8787998
|
0.5585619
|
1.3826383
|
0.5763279
|
|
30-days mortality
|
Younger than 60 years
|
Last vaccine received more than 180 days ago
|
1.6080163
|
0.9920747
|
2.6063727
|
0.0538958
|
|
30-days mortality
|
60 years or older
|
Last vaccine received 31-90 days ago
|
0.8313884
|
0.7133280
|
0.9689887
|
0.0181225
|
|
30-days mortality
|
60 years or older
|
Last vaccine received 91-180 days ago
|
1.3703419
|
1.1780244
|
1.5940560
|
0.0000444
|
|
30-days mortality
|
60 years or older
|
Last vaccine received more than 180 days ago
|
1.6845434
|
1.4113076
|
2.0106790
|
0.0000000
|
General analysis of the infection risk by time since last EXPOSURE
Risk (Odds Ratio) for the outcomes of interest by time since last exposure.
|
Outcome of interest
|
Time past since last exposure
|
OR
|
OR lower CI limit
|
OR upper CI limit
|
p value
|
|
Hospital admission
|
Last exposed 31-90 days ago days
|
0.8351485
|
0.7747440
|
0.9002627
|
0.0000026
|
|
Hospital admission
|
Last exposed 91-180 days ago days
|
1.1187989
|
1.0378740
|
1.2060337
|
0.0033854
|
|
Hospital admission
|
Last exposed more than 180 days ago days
|
1.2698662
|
1.1661326
|
1.3828274
|
0.0000000
|
|
ICU admission
|
Last exposed 31-90 days ago days
|
0.8191441
|
0.6462963
|
1.0382189
|
0.0989857
|
|
ICU admission
|
Last exposed 91-180 days ago days
|
0.9969209
|
0.7813727
|
1.2719300
|
0.9802066
|
|
ICU admission
|
Last exposed more than 180 days ago days
|
0.9759640
|
0.7428946
|
1.2821545
|
0.8612736
|
|
30-days mortality
|
Last exposed 31-90 days ago days
|
0.8479066
|
0.7250133
|
0.9916309
|
0.0389075
|
|
30-days mortality
|
Last exposed 91-180 days ago days
|
0.9985877
|
0.8539976
|
1.1676584
|
0.9858710
|
|
30-days mortality
|
Last exposed more than 180 days ago days
|
1.1727437
|
0.9824877
|
1.3998422
|
0.0776742
|
General analysis of the infection risk by time since last EXPOSURE (2 age groups)
Risk (Odds Ratio) for the outcomes of interest by time since last exposure.
|
Outcome of interest
|
Age group
|
Time past since last vaccine dose
|
OR
|
OR lower CI limit
|
OR upper CI limit
|
p value
|
|
Hospital admission
|
Younger than 60 years
|
Last exposed 31-90 days ago
|
0.9878722
|
0.8631244
|
1.1306498
|
0.8593837
|
|
Hospital admission
|
Younger than 60 years
|
Last exposed 91-180 days ago
|
0.9905512
|
0.8638855
|
1.1357890
|
0.8918234
|
|
Hospital admission
|
Younger than 60 years
|
Last exposed more than 180 days ago
|
1.3296247
|
1.1527344
|
1.5336593
|
0.0000918
|
|
Hospital admission
|
60 years or older
|
Last exposed 31-90 days ago
|
0.8372125
|
0.7635551
|
0.9179753
|
0.0001559
|
|
Hospital admission
|
60 years or older
|
Last exposed 91-180 days ago
|
1.1927728
|
1.0870550
|
1.3087717
|
0.0001971
|
|
Hospital admission
|
60 years or older
|
Last exposed more than 180 days ago
|
1.5514686
|
1.3914661
|
1.7298695
|
0.0000000
|
|
ICU admission
|
Younger than 60 years
|
Last exposed 31-90 days ago
|
1.0609106
|
0.7100129
|
1.5852265
|
0.7729138
|
|
ICU admission
|
Younger than 60 years
|
Last exposed 91-180 days ago
|
0.8499232
|
0.5599323
|
1.2901014
|
0.4450555
|
|
ICU admission
|
Younger than 60 years
|
Last exposed more than 180 days ago
|
1.0532768
|
0.6817876
|
1.6271813
|
0.8150612
|
|
ICU admission
|
60 years or older
|
Last exposed 31-90 days ago
|
0.8984086
|
0.6620025
|
1.2192371
|
0.4916862
|
|
ICU admission
|
60 years or older
|
Last exposed 91-180 days ago
|
0.8963117
|
0.6518076
|
1.2325334
|
0.5005980
|
|
ICU admission
|
60 years or older
|
Last exposed more than 180 days ago
|
1.0743622
|
0.7487770
|
1.5415192
|
0.6969943
|
|
30-days mortality
|
Younger than 60 years
|
Last exposed 31-90 days ago
|
0.9588818
|
0.6164412
|
1.4915525
|
0.8522351
|
|
30-days mortality
|
Younger than 60 years
|
Last exposed 91-180 days ago
|
0.8846779
|
0.5630222
|
1.3900962
|
0.5951179
|
|
30-days mortality
|
Younger than 60 years
|
Last exposed more than 180 days ago
|
1.6119320
|
0.9955152
|
2.6100305
|
0.0521754
|
|
30-days mortality
|
60 years or older
|
Last exposed 31-90 days ago
|
0.8308486
|
0.7128524
|
0.9683763
|
0.0177329
|
|
30-days mortality
|
60 years or older
|
Last exposed 91-180 days ago
|
1.3750533
|
1.1822077
|
1.5993565
|
0.0000361
|
|
30-days mortality
|
60 years or older
|
Last exposed more than 180 days ago
|
1.6636414
|
1.3939861
|
1.9854593
|
0.0000000
|
Upset Plot for describing categories
# upset(data=vacunas, intersections = NOM_VACUNA,group.by = COD_NUHSA_ENCRIPTADO, order.by = "freq")
Rentabilidad Edad
# Definir los parámetros
# costo_hospitalizacion <- 4612.76
# precio_vacuna <- 31
# dosis_equiv <- 148
# nnt <- 148
# red_abs_riesgo <- 0.0068
# Definir un vector de edades de 18 a 120
# edades <- 18:120
# Calcular la rentabilidad para cada edad
# rentabilidad <- (costo_hospitalizacion/dosis_equiv) / nnt / (1 - red_abs_riesgo)
# Crear un dataframe con los resultados
# df <- data.frame(edad = edades, rentabilidad = rentabilidad)
